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<?xml version="1.0" encoding="UTF-8" ?><!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.0 20040830//EN" "http://dtd.nlm.nih.gov/publishing/2.0/journalpublishing.dtd"> |
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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" |
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article-type="other" dtd-version="2.0" xml:lang="EN"> |
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<front> |
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<journal-meta> |
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<journal-id journal-id-type="nlm-ta">PLoS Comput Biol</journal-id> |
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<journal-id journal-id-type="publisher-id">plos</journal-id> |
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<journal-id journal-id-type="pmc">ploscomp</journal-id> |
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<journal-title>PLoS Computational Biology</journal-title> |
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<issn pub-type="epub">1553-7358</issn> |
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<publisher> |
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<publisher-name>Public Library of Science</publisher-name> |
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<publisher-loc>San Francisco, USA</publisher-loc> |
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</publisher> |
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</journal-meta> |
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<article-meta> |
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<article-id pub-id-type="doi">10.1371/image.pcbi.v04.i07</article-id> |
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<article-categories> |
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<subj-group subj-group-type="heading"> |
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<subject>Issue Image</subject> |
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</subj-group> |
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</article-categories> |
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<title-group> |
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<article-title><italic>PLoS Computational Biology</italic> Issue Image | Vol. 4(7) |
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July 2008</article-title> |
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<alt-title alt-title-type="running-head">Issue Image</alt-title> |
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</title-group> |
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<pub-date pub-type="collection"> |
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<month>7</month> |
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<year>2008</year> |
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</pub-date> |
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<pub-date pub-type="epub"> |
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<day>25</day> |
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<month>7</month> |
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<year>2008</year> |
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</pub-date> |
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<volume>4</volume> |
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<issue>7</issue> |
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<elocation-id>ev04.i07</elocation-id> |
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<copyright-statement>Teotico et al. This is an open-access article distributed under the |
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terms of the Creative Commons Attribution License, which permits unrestricted use, |
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distribution, and reproduction in any medium, provided the original author and |
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source are credited.</copyright-statement> |
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<copyright-year>2008</copyright-year> |
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<abstract> |
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<title> |
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<bold>Long-range correlated motions are essential for nuclear receptor activity. |
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</bold> |
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</title> |
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<p>AF-2 domains of nuclear receptors mediate crucial protein–protein |
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interactions with transcriptional coactivators. The AF-2 domains (magenta) of |
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the human nuclear xenobiotic receptor PXR (cyan) were demonstrated using |
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molecular dynamics to move together in an "active-ready" conformation, poised to |
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bind to their cognate protein partners (see <ext-link ext-link-type="uri" |
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xlink:href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000111" |
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>Teotico et al.</ext-link> pcbi.1000111). Other nuclear receptors were also |
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shown to follow suit.</p> |
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<p><italic>Image Credit: Monica Frazier and Matthew Redinbo</italic></p> |
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</abstract> |
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</article-meta> |
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</front> |
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<body> |
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<sec id="s1"> |
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<title/> |
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<fig id="image-pcbi-v04-i07-g001"> |
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<object-id pub-id-type="doi">10.1371/image.pcbi.v04.i07.g001</object-id> |
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<caption> |
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<title> |
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<bold>Long-range correlated motions are essential for nuclear receptor |
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activity. </bold> |
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</title> |
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<p>AF-2 domains of nuclear receptors mediate crucial protein–protein |
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| 73 |
interactions with transcriptional coactivators. The AF-2 domains (magenta) |
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| 74 |
of the human nuclear xenobiotic receptor PXR (cyan) were demonstrated using |
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| 75 |
molecular dynamics to move together in an "active-ready" conformation, |
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| 76 |
poised to bind to their cognate protein partners (see <ext-link |
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ext-link-type="uri" |
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| 78 |
xlink:href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000111" |
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| 79 |
>Teotico et al.</ext-link> pcbi.1000111). Other nuclear receptors were |
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| 80 |
also shown to follow suit.</p> |
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| 81 |
<p><italic>Image Credit: Monica Frazier and Matthew Redinbo</italic></p> |
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</caption> |
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<graphic xlink:href="image.pcbi.v04.i07.g001.tif"/> |
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<attrib>Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BRS, et al. (2008) |
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Active Nuclear Receptors Exhibit Highly Correlated AF-2 Domain Motions. PLoS |
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Comput Biol 4(7): e1000111. doi:10.1371/journal.pcbi.1000111</attrib> |
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<copyright-statement>© 2008 Teotico et al</copyright-statement> |
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</fig> |
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</sec> |
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</body> |
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<back/> |
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</article> |
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